Pancreatic islet β-cells exhibit tremendous plasticity for secretory adaptations that coordinate
insulin production and release with nutritional demands. This essential feature of the β-cell …

Post-translational modification (PTM) has a significant impact on cellular signaling and
function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell …

ER stress and proinsulin misfolding are heralded as contributing factors to β cell dysfunction
in type 2 diabetes, yet how ER function becomes compromised is not well understood …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are
membrane-associated trafficking proteins that confer identity to lipid membranes and …

Pancreatic β cells dedicate much of their protein translation capacity to producing insulin to
maintain glucose homeostasis. In response to increased secretory demand, β cells can …

Diabetes is a systemic disease, and its progression involves multiple organ dysfunction.
However, the exact mechanisms underlying pathological progression remain unclear. Small …

SUMOylation reduces oxidative stress and preserves islet mass at the expense of robust
insulin secretion. To investigate a role for the deSUMOylating enzyme sentrin-specific …

As one of the most widespread chronic diseases, diabetes and its accompanying
complications affect approximately one tenth of individuals worldwide and represent a …

Post-translational modification (PTM) plays a crucial role in adaptation of mammals to
environmental changes, enabling them to survive in stressful situations. One such PTM is …

Insulin-secreting β-cells in the pancreatic islets are exposed to various endogenous and
exogenous stressing conditions, which may lead to β-cell dysfunction or apoptosis and …