The upward extend of malaria collectively with the emergence of resistance against
predictable drugs has put enormous pressure on public health systems to introduce new …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

Cinnamic acids are compounds of natural origin that can be found in many different parts of
a wide panoply of plants, where they play the most diverse biological roles, often in a …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …

The control of malaria is challenged by drug resistance, and new antimalarial drugs are
needed. New drug discovery efforts include consideration of hybrid compounds as potential …

Harmicines constitute novel hybrid compounds that combine two agents with reported
antiplasmodial properties, namely β-carboline harmine and a cinnamic acid derivative …

Primaquine–pyrimidine hybrids: Synthesis and dual-stage antiplasmodial activity -
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The rise of the resistance of the malaria parasite to the currently approved therapy urges the
discovery and development of new efficient agents. Previously we have demonstrated that …