Nuclear Transplantation, Embryonic Stem Cells, and the Potential for Cell Therapy | New
England Journal of Medicine Skip to main content The New England Journal of Medicine …

An efficient animal cloning technology would provide many new opportunities for livestock
agriculture, human medicine, and animal conservation. Nuclear cloning involves the …

Several studies have shown that both quiescent and proliferating somatic donor cells can be
fully reprogrammed after nuclear transfer (NT) and result in viable offspring. So far, however …

Stem cells from farm animals are valuable cell models for the study of development,
differentiation, and are potential efficient donors for nuclear transfer. Here we report the …

The African wild cat is one of the smallest wild cats and its future is threatened by
hybridization with domestic cats. Nuclear transfer, a valuable tool for retaining genetic …

The significance of donor cell differentiation status for successful cloning by somatic cell
nuclear transfer (SCNT) is unclear. Here, we cloned a new species, red deer (Cervus …

The cell cycle stage of donor cells is an important factor influencing developmental ability of
nuclear transfer embryos. In the present experiment, cumulus and fibroblast cells of cattle …

Over the past six years, hundreds of apparently normal calves have been cloned worldwide
from bovine somatic donor cells. However, these surviving animals represent less than 5 …

Previous studies have demonstrated that increased histone acetylation in donor cells or
cloned embryos, by applying a histone deacetylase inhibitor (HDACi) such as trichostatin A …

The generation of adult animals by nuclear cloning from adult donor cells is extremely
inefficient, with most clones dying soon after implantation. In contrast, cloning from …