The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

Understanding the function of eukaryotic genomes, including the human genome, is
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …

In chromatin replication, faithful recycling of histones from parental DNA to replicated strands
is essential for maintaining epigenetic information across generations. A previous …

DNA translocases, such as RNA polymerases, inevitably collide with nucleosomes on
eukaryotic chromatin. Upon these collisions, histone chaperones are suggested to facilitate …

During replication, expression, and repair of the eukaryotic genome, cellular machinery must
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …

Nuclear processes depend on the organization of chromatin, whose basic units are cylinder-
shaped complexes called nucleosomes. A subset of mammalian nucleosomes in situ (inside …

Due to the vast length scale inside the cell nucleus, multiscale models are required to
understand chromatin folding, structure, and dynamics and how they regulate genomic …

The organization of Eukaryotic DNA into chromatin has profound implications for the
processing of genetic information. In the past years, molecular dynamics (MD) simulations …

The nucleosome, which organizes the long coil of genomic DNA in a highly condensed,
polymeric way, is thought to be the basic unit of chromosomal structure. As the most …

The nucleosome including H2A. B, a mammalian-specific H2A variant, plays pivotal roles in
spermatogenesis, embryogenesis, and oncogenesis, indicating unique involvement in …