Drug delivery and drug targeting with parenteral lipid nanoemulsions—A review

K Hörmann, A Zimmer - Journal of controlled release, 2016 - Elsevier
Lipid nanosized emulsions or nanoemulsions (NE) are oil in water dispersions with an oil
droplet size of about 200 nm. This size of oil droplets dispersed in a continuous water phase …

Vegetable oils in pharmaceutical and cosmetic lipid-based nanocarriers preparations

JF Masiero, EJ Barbosa, L de Oliveira Macedo… - Industrial Crops and …, 2021 - Elsevier
The use of vegetable oils in lipid nanoparticle preparation is a promising field for treating
diverse pathologies. Developing these particles requires advanced knowledge of …

Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy

J Wang, J Tan, J Luo, P Huang, W Zhou, L Chen… - Journal of …, 2017 - Springer
Background Diabetic retinopathy is the most common complication in diabetic patients
relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be …

Preparation, characterization, and evaluation of breviscapine nanosuspension and its freeze-dried powder

T Zhang, X Li, J Xu, J Shao, M Ding, S Shi - Pharmaceutics, 2022 - mdpi.com
As a biopharmaceutics classification system (BCS) class IV drug, breviscapine (Bre) has low
solubility in water, poor chemical stability, a short biological half-life and rapid removal from …

Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke

MH Ri, Y Xing, HX Zuo, MY Li, HL Jin, J Ma, X Jin - Phytomedicine, 2023 - Elsevier
Background Development of clinically effective neuroprotective agents for stroke therapy is
still a challenging task. Microglia play a critical role in brain injury and recovery after …

Self-emulsifying drug delivery system and the applications in herbal drugs

L Zhang, lanying Zhang, M Zhang, Y Pang, Z Li… - Drug …, 2015 - Taylor & Francis
Herbal drugs have been used for thousands of years in the east and have had a recent
resurgence in popularity among consumers in the west. However, most of herbal drug are …

Intravenous administration of scutellarin nanoparticles augments the protective effect against cerebral ischemia–reperfusion injury in rats

C Yang, Q Zhao, S Yang, L Wang, X Xu… - Molecular …, 2022 - ACS Publications
This study investigates the protective effect of poly (lactic-co-glycolic acid)(PLGA)
nanoparticles (NPs) loaded with scutellarin (SCU), a flavone isolated from the traditional …

Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats

C Guo, Y Zhu, Y Weng, S Wang, Y Guan, G Wei… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance Breviscapine injection is a Chinese herbal medicine
standardized product extracted from Erigeron breviscapus (Vant.) Hand.-Mazz. It has been …

Synthesis and characterization of cycloaliphatic hydrophilic polyurethanes, modified with L-ascorbic acid, as materials for soft tissue regeneration

J Kucinska-Lipka, I Gubanska, M Strankowski… - Materials Science and …, 2017 - Elsevier
In this paper we described synthesis and characteristic of obtained hydrophilic
polyurethanes (PURs) modified with ascorbic acid (commonly known as vitamin C). Such …

Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery—Part I: parenteral applications

JB Cannon, Y Shi, P Gupta - Water-insoluble drug formulation, 2018 - taylorfrancis.com
This chapter focuses on the usefulness of emulsion systems for the delivery of water-
insoluble compounds for parenteral administration. Emulsions for parenteral use should …