Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most
Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave
gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the …

The human non-canonical inflammasome controls caspase-4 activation and gasdermin-D-
dependent pyroptosis in response to cytosolic bacterial lipopolysaccharide (LPS). Since …

A fundamental concept in immunology is that the innate immune system initiates or instructs
downstream adaptive immune responses. Inflammasomes are central players in innate …

Neutrophil extrusion of neutrophil extracellular traps (NETs) and concomitant cell death
(NETosis) provides host defense against extracellular pathogens, whereas macrophage …