Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Genetically encoded fluorescent indicators have transformed the way neuroscientists record
neuronal activities and interrogate the nervous system in vivo. In this review, we discuss …

Although many Zn2+ fluorescent probes have been developed, there remains a lack of
consensus on the labile Zn2+ concentrations ([Zn2+]) in several cellular compartments, as …

Genetically-encoded biosensors based on a single fluorescent protein are widely used to
visualize analyte levels or enzymatic activities in cells, though usually to monitor relative …

Abstract Zinc (Zn 2+) is an essential micronutrient that is required for a wide variety of
cellular processes. Tools and methods have been instrumental in revealing the myriad roles …

Zinc is an essential micronutrient required for all domains of life. Cells maintain zinc
homeostasis using a network of transporters, buffers, and transcription factors. Zinc is …

The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic
leukemia has generated interest in elucidating how these mutations contribute to oncogenic …

Zinc is a highly abundant cation in the brain, essential for cellular functions, including
transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious …

Zinc is widely recognized as essential for growth and proliferation, yet the mechanisms of
how zinc deficiency arrests these processes remain enigmatic. Here we induce subtle zinc …

A series of diketopyrrolopyrrole-based fluorescent probes (DPP-C2, LysoDPP-C2, LysoDPP-
C3, and LysoDPP-C4) have been developed for the detection of low pH and Zn2+ in an …