Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

Absence of the spleen or splenic function predisposes individuals to risk of overwhelming
infection. These infections are most often due to encapsulated organisms, especially …

Seven children with chronic or intermittent and six with acute idiopathic thrombocytopenic
purpura (ITP) were treated with large intravenous doses of polyvalent, intact immunoglobulin …

Abstract The Wiskott-Aldrich syndrome is an X-linked primary immunodeficiency originally
characterized by the clinical triad of thrombocytopenia, eczema, and immunodeficiency. We …

A large proportion of patients with mutations in the Wiskott-Aldrich syndrome (WAS) protein
gene exhibit the milder phenotype termed X-linked thrombocytopenia (XLT). Whereas stem …

▪ Abstract The Wiskott-Aldrich Syndrome (WAS) is a rare X-linked primary immunodeficiency
that is characterized by recurrent infections, hematopoietic malignancies, eczema, and …

The importance of the cytoskeleton in mounting a successful immune response is evident
from the wide range of defects that occur in actin‐related primary immunodeficiencies (PID …

This study describes the effects of two major treatment options, splenectomy and/or bone
marrow transplantation, on the natural history of the Wiskott-Aldrich (WAS) syndrome. The …

The spleen serves two major critical functions in protecting against bloodstream bacterial
infections--it is a phagocytic filter that removes bacteria from the bloodstream and it is an …

Wiskott, in 1937, described three brothers who presented shortly after birth with
thrombocytopenia, bloody diarrhea, eczema, and recurrent ear infections [104] …