Nanotechnology-based antitumor drug delivery systems, known as nanocarriers, have
demonstrated their efficacy in recent years. Typically, the size of the nanocarriers is around …

Osteosarcoma is the most common primary malignant bone tumor in children and young
adults. The standard-of-care curative treatment for osteosarcoma utilizes doxorubicin …

Nanomedicines can effectively penetrate tumor sites compared to traditionally used drugs.
However, effective drugs that reach the interior of tumors remain limited. Based on studies of …

Liposomes are widely used for systemic delivery of chemotherapeutic agents to reduce their
nonspecific side effects. Gemcitabine (Gem) makes a great candidate for liposomal …

Hearing loss is the most common neurosensory impairment worldwide. While conductive
hearing loss can be managed by surgery, the management of sensorineural hearing loss …

The genesis of cell-penetrating peptide research (CPP; also known as prote/peptide
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …

Lung cancer is often diagnosed at an advanced stage where tumors are usually inoperable
and first-line therapies are inefficient and have off-targeted adverse effects, resulting in poor …

Cell-penetrating peptides represent an emerging class of carriers capable of effective
cellular delivery. This work demonstrates the preparation and investigation of efficient CPPs …

The fight against drug resistance in chemotherapy requires a molecular-level understanding
of the drug interaction with cell membranes, which today is feasible with membrane models …

Background Doxorubicin (DOX) is one of the most effective treatments for hepatocellular
carcinoma (HCC), but is restricted by its poor pharmacokinetics. Herein, we exploited …