Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …

The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …

The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism.
PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate+ ATP→ PRPP+ …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Resistance against currently used antitubercular therapeutics increasingly undermines
efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) …

Relapse is the leading cause of mortality in children with acute lymphoblastic leukemia
(ALL). Among chemotherapeutics, thiopurines are key drugs in ALL combination therapy …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …