The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

We use fluorescence microscopy to directly observe liquid phases in giant unilamellar
vesicles. We find that a long list of ternary mixtures of high melting temperature (saturated) …

Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid
β-peptide (Aβ) and degeneration of neurons in brain regions such as the hippocampus …

There has been considerable recent interest in the possibility that the plasma membrane
contains lipid" rafts," microdomains enriched in cholesterol and sphingolipids. It has been …

Fibroblast to myofibroblast differentiation drives effective wound healing and is largely
regulated by the cytokine transforming growth factor-β1 (TGF-β1). Myofibroblasts express α …

The bulk structure of biological membranes consists of a bilayer of amphipathic lipids.
According to the fluid mosaic model proposed by Singer and Nicholson, the …

Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival
factor for midbrain dopaminergic neurons. GDNF and related ligands, neurturin (NRTN) …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

The variety of diseases caused by mutations in RET receptor tyrosine kinase provides a
classic example of phenotypic heterogeneity. Gain-of-function mutations of RET are …