Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …

Objective: Exosomes are nanovesicles that are released from normal and tumor cells and
are detectable in cell culture supernatant and human biological fluids. Although previous …

Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which
is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is …

Melanoma represents a significant malignancy in humans and dogs. Different from
genetically engineered models, sporadic canine melanocytic neoplasms share several …

Despite recent advances in treatment, overall survival rates for metastatic melanoma,
especially those that invade the lungs, continue to be low, with 5-year survival rates of only …

Abstract Background Porphyrin TMPyP4 (P4) and its C 14 H 28-alkyl derivative (C14) are G-
quadruplex binders and singlet oxygen (1 O 2) generators. In contrast, TMPyP2 (P2) …

Mucosal melanoma (MM) is a highly lethal variant of melanoma that carries a poor
prognosis. Extremely low incidence and survival rates have led to few clinical trials, and a …

Recent discoveries have increased our comprehension of the molecular signaling events
critical for melanoma development and progression. Many oncogenes driving melanoma …

Over the past 3 decades, several breakthroughs have greatly expanded what is known
about melanocyte biology, relevant oncogenic mutations and deletions and amplifications in …

Melanoma is a malignant tumor with high rate of metastasis and poor prognosis. How
melanoma develops and how to treat it will continue to be a hot topic. This review briefly …