B cell epitope mapping: The journey to better vaccines and therapeutic antibodies

AJ De Leon, MC Tjiam, Y Yu - … et Biophysica Acta (BBA)-General Subjects, 2024 - Elsevier
B-cell epitope mapping is an approach that can identify and characterise specific antigen
binding sites of B-cell receptors and secreted antibodies. The ability to determine the …

The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms

MF Flajnik - Immunological Reviews, 2024 - Wiley Online Library
The study of antibodies in jawed vertebrates (gnathostomes) provides every immunologist
with a bird's eye view of how human immunoglobulins (Igs) came into existence and …

Estimates of Sequences with Ultralong and Short CDR3s in the Bovine IgM B Cell Receptor Repertoire Using the Long-read Oxford Nanopore MinION Platform

TE Altvater-Hughes, HP Hodgins, DC Hodgins… - …, 2024 - academic.oup.com
Cattle produce Abs with an H chain ultralong CDR3 (40–70 aa). These Abs have been
shown to have features such as broad neutralization of viruses and are investigated as …

[HTML][HTML] Investigating the IgM and IgG B Cell Receptor Repertoires and Expression of Ultralong Complementarity Determining Region 3 in Colostrum and Blood from …

TE Altvater-Hughes, HP Hodgins, DC Hodgins… - Animals, 2024 - mdpi.com
Simple Summary Newborn calves rely on consuming the first milk, colostrum, to transfer
important proteins and cells for protection from pathogens. Lymphocytes compose a fraction …

RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia

T Kalbfleisch, S McKay, B Murdoch, DL Adelson… - 2024 - researchsquare.com
The publication of the first complete, haploid telomere-to-telomere (T2T) human genome
revealed new insights into the structure and function of the heretofore “invisible” parts of the …

[PDF][PDF] Primer Design and Amplification of IgM Antibody Repertoire of Philippine Carabao (Bubalus kerabau Fitzinger, 1860) for Construction of Phage Display Library.

DC Licayan, CP Ameril, LL Ilag… - Philippine Journal of …, 2024 - philjournalsci.dost.gov.ph
Antibody display library is a robust platform for the production of recombinant or monoclonal
antibodies that are of great value in diagnostics and therapeutics. A naïve library constructed …

Differential analysis of immunoglobulin gene expression pattern in chickens of distinct breeds and developmental periods

Y Qiu, X Yi, X Tang, Y Wei, B Zhang… - Journal of Animal …, 2024 - academic.oup.com
Immunoglobulin is an essential component of the body's defense against pathogens, aiding
in the recognition and clearance of foreign antigens. Research concerning immunoglobulin …