Emergence and developmental roles of the cerebrospinal fluid system
RM Fame, MK Lehtinen - Developmental cell, 2020 - cell.com
We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …
Hedgehog signal and genetic disorders
N Sasai, M Toriyama, T Kondo - Frontiers in Genetics, 2019 - frontiersin.org
The hedgehog (Hh) family comprises sonic hedgehog (Shh), Indian hedgehog (Ihh), and
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …
Whole-cell organelle segmentation in volume electron microscopy
Cells contain hundreds of organelles and macromolecular assemblies. Obtaining a
complete understanding of their intricate organization requires the nanometre-level, three …
complete understanding of their intricate organization requires the nanometre-level, three …
[HTML][HTML] A cellular and spatial map of the choroid plexus across brain ventricles and ages
The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …
forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP …
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
Genome-wide association studies (GWAS) have identified loci for kidney disease, but the
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
causal variants, genes, and pathways remain unknown. Here we identify two kidney disease …
The ESCRT-machinery: closing holes and expanding roles
AT Gatta, JG Carlton - Current opinion in cell biology, 2019 - Elsevier
The ESCRT machinery is an ancient, evolutionarily conserved membrane remodelling
complex that is deployed by cells to perform a diverse collection of physiological and …
complex that is deployed by cells to perform a diverse collection of physiological and …
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells
NV Ayala-Nunez, G Follain, F Delalande… - Nature …, 2019 - nature.com
Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe
neurological diseases. However the virus journey, from the bloodstream to tissues through a …
neurological diseases. However the virus journey, from the bloodstream to tissues through a …
A review on protein markers of exosome from different bio-resources and the antibodies used for characterization
F Deng, J Miller - Journal of Histotechnology, 2019 - Taylor & Francis
Exosomes are small membrane vesicles (ranging from 30 nm to 150 nm), secreted by
different cell types upon fusion of multivesicular bodies (MVB) to the cell plasma membrane …
different cell types upon fusion of multivesicular bodies (MVB) to the cell plasma membrane …
Tracking calcium dynamics and immune surveillance at the choroid plexus blood-cerebrospinal fluid interface
The choroid plexus (ChP) epithelium is a source of secreted signaling factors in
cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop …
cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we develop …
Innovations in 3D tissue models of human brain physiology and diseases
ML Lovett, TJF Nieland, YTL Dingle… - Advanced functional …, 2020 - Wiley Online Library
Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …
culture systems that do not recapitulate native cell behavior. The discrepancy between in …