Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Several nitrogen heterocyclic analogues have been applied to clinical practice, and about
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …

Abstract Using Pd (PPh 3) 4 as a catalyst, a new series of coupling products (5a–5l)
synthesized from pyrazole derivatives (4a-4c) and substituted boronic acids. Afterward, 1 H …

Chagas disease is a tropical neglected disease that affects millions of people worldwide, still
demanding a more effective and safer therapy, especially in its chronic phase which lacks a …

Introduction Benznidazole, the drug of choice for treating Chagas Disease (CD), has
significant limitations, such as poor cure efficacy, mainly in the chronic phase of CD …

Chagas disease, a century-old disease that mainly affects the impoverished population in
Latin America, causes high morbidity and mortality in endemic countries. The available …

The Cu2+ complexes of three [1+ 1] azacyclophane macrocycles having the 1H-pyrazole
ring as the spacer and the pentaamine 1, 5, 8, 11, 15-pentaazadecane (L1) or hexaamines …

Chagas disease, a silent but widespread disease that mainly affects a socioeconomically
vulnerable population, lacks innovative safe drug therapy. The available drugs …

Simple Summary Chagas disease, caused by the protozoan Trypanosoma cruzi, is a
neglected tropical disease that affects 6–7 million people worldwide. It is a global disease …

Neglected tropical diseases (NTDs), particularly those caused by trypanosomatid protozoa,
impose a significant global burden, disproportionately affecting underserved communities in …