The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Resistance to insulin is a pathophysiological state related to the decreased response of
peripheral tissues to the insulin action, hyperinsulinemia and raised blood glucose levels …

Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …

Insulin resistance is a multi-faceted disruption of the communication between insulin and the
interior of a target cell. The underlying cause of insulin resistance appears to be …