Cell fate specification and differentiation in the adult mammalian intestine

J Beumer, H Clevers - Nature reviews Molecular cell biology, 2021 - nature.com
Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

[HTML][HTML] Targeting gut microbiota and metabolism as the major probiotic mechanism-An evidence-based review

T Ma, X Shen, X Shi, HA Sakandar, K Quan, Y Li… - Trends in Food Science …, 2023 - Elsevier
Background The human gut hosts complex microbial communities, which are linked to
health and disease. The gut microbiota is continuously reshaped by multiple environmental …

Matrix viscoelasticity controls spatiotemporal tissue organization

A Elosegui-Artola, A Gupta, AJ Najibi, BR Seo… - Nature materials, 2023 - nature.com
Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

Cell fate coordinates mechano-osmotic forces in intestinal crypt formation

Q Yang, SL Xue, CJ Chan, M Rempfler, D Vischi… - Nature Cell …, 2021 - nature.com
Intestinal organoids derived from single cells undergo complex crypt–villus patterning and
morphogenesis. However, the nature and coordination of the underlying forces remains …

Adherens junctions as molecular regulators of emergent tissue mechanics

O Campàs, I Noordstra, AS Yap - Nature Reviews Molecular Cell …, 2024 - nature.com
Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

C Pérez-González, G Ceada, F Greco, M Matejčić… - Nature cell …, 2021 - nature.com
Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …

The role of single-cell mechanical behaviour and polarity in driving collective cell migration

S Jain, VML Cachoux, GHNS Narayana, S de Beco… - Nature physics, 2020 - nature.com
The directed migration of cell collectives is essential in various physiological processes,
such as epiboly, intestinal epithelial turnover, and convergent extension during …

Measuring mechanical stress in living tissues

M Gómez-González, E Latorre, M Arroyo… - Nature Reviews …, 2020 - nature.com
Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

Mechanical state transitions in the regulation of tissue form and function

Y Mao, SA Wickström - Nature Reviews Molecular Cell Biology, 2024 - nature.com
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

Intestinal plasticity and metabolism as regulators of organismal energy homeostasis

O Stojanović, I Miguel-Aliaga, M Trajkovski - Nature metabolism, 2022 - nature.com
The small intestine displays marked anatomical and functional plasticity that includes
adaptive alterations in adult gut morphology, enteroendocrine cell profile and their hormone …