Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of
nervous systems in both invertebrates and vertebrates. It has been proposed for several …

The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Muscle paralysis after spinal cord injury is partly caused by a loss of brainstem-derived
serotonin (5-HT), which normally maintains motoneuron excitability by regulating crucial …

After spinal cord injury (SCI), various sensorimotor functions can recover, ranging from
simple spinal reflexes to more elaborate motor patterns, such as locomotion. Locomotor …

Spasticity, resulting in involuntary and sustained contractions of muscles, may evolve in
patients with stroke, cerebral palsy, multiple sclerosis, brain injury, and spinal cord injury …

The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …

Persistent inward currents (PICs) are present in many types of neurons and likely have
diverse functions. In spinal motoneurons, PICs are especially strong, primarily located in …

Serotonergic neuromodulation contributes to enhanced voluntary muscle activation.
However, it is not known how the likely motoneurone receptor candidate (5‐HT2) influences …

Motor fatigue induced by physical activity is an everyday experience characterized by a
decreased capacity to generate motor force. Factors in both muscles and the central nervous …