BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all,
human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms …

Differences in immune responses to viruses and autoimmune diseases such as systemic
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …

Immune signatures measured at baseline and immediately prior to vaccination may predict
the immune response to vaccination. Such pre-vaccine assessment might allow not only …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain.
We show that moderate-grade fever temperatures (39° C) increased murine CD4 T cell …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

In malaria-naïve children and adults, Plasmodium falciparum-infected red blood cells (Pf-
iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic …

Several infectious and autoimmune diseases are associated with an expansion of CD21−
CD27− atypical B cells (atBCs) that up-regulate inhibitory receptors and exhibit altered B cell …

Combinations of monoclonal antibodies (mAbs) against different epitopes on the same
antigen synergistically neutralize many viruses. However, there are limited studies …