Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

An effective host defense mechanism involves inflammation to eliminate pathogens from the
site of infection, followed by the resolution of inflammation and the restoration of tissue …

▪ Abstract Tight junctions form continuous intercellular contacts controlling solute movement
through the paracellular pathway across epithelia. Paracellular barriers vary among …

The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …

The popular view that all lipid mediators are pro-inflammatory arises largely from the finding
that nonsteroidal anti-inflammatory drugs block the biosynthesis of prostaglandins. The …

The resolution of the inflammatory response is highly regulated by the timely biosynthesis of
a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers …

Inflammation and its timely resolution are critical to ensure effective host defense and
appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation …

Claudins are a family of tight junction membrane proteins that regulate paracellular
permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are …

The molecular basis for the beneficial impact of essential omega-3 (n− 3) FA remains of
interest. Recently, we identified novel mediators generated from eicosapentaenoic acid …

Urinary exosomes are excreted from all nephron segments and constitute a rich source of
intracellular kidney injury biomarkers. To study whether they contain transcription factors, we …