Abstract The Collaborative Cross Consortium reports here on the development of a unique
genetic resource population. The Collaborative Cross (CC) is a multiparental recombinant …

The laboratory mouse is an artificial construct with a complex relationship to its natural
ancestors. In 2002, the mouse became the first mammalian model organism with a reference …

Genetic tests can help clinicians to diagnose rare monogenic liver diseases. For most
common liver diseases, however, multiple gene variants that have small to moderate …

Previous genetic association studies of physical activity, in both animal and human models,
have been limited in number of subjects and genetically homozygous strains used as well …

The main cause of Parkinson's disease (PD) remains unknown and the pathologic changes
in the brain limit rapid diagnosis. Herein, differentially expressed genes (DEGs) in the Gene …

Rationale: Because acute lung injury is a sporadic disease produced by heterogeneous
precipitating factors, previous genetic analyses are mainly limited to candidate gene case …

The tripeptide glutathione (GSH) is instrumental to antioxidant protection and xenobiotic
metabolism, and the ratio of its reduced and oxidized forms (GSH/GSSG) indicates the …

Glutathione redox balance—defined as the ratio GSH/GSSG—is a critical regulator of
cellular redox state, and declines in this ratio are closely associated with oxidative stress …

During ischemic stroke, occlusion of the cerebrovasculature causes neuronal cell death
(infarction), but naturally occurring genetic factors modulating infarction have been difficult to …

The genetic basis for the underlying individual susceptibility to chlorine-induced acute lung
injury is unknown. To uncover the genetic basis and pathophysiological processes that …