Our immune system has evolved as a complex network of cells and tissues tasked with
maintaining host homeostasis. This is evident during the inflammatory responses elicited …

Glucocorticoids (GCs) are a class of steroid hormones secreted from the adrenal cortex.
Their production is controlled by circadian rhythm and stress, the latter of which includes …

The glucocorticoid receptor is an important immunosuppressive drug target and metabolic
regulator that acts as a ligand-gated transcription factor. Generally, GR's anti-inflammatory …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells and natural inhibitors of adaptive immunity. Intracellular metabolic changes in MDSCs …

Glucocorticoids are potent anti-inflammatory drugs that are used to treat an extraordinary
range of human disease, including COVID-19, underscoring the ongoing importance of …

IgE mediates allergic responses by coating mast cell or basophil surfaces and inducing
degranulation upon binding a specific allergen. IgE can also be spontaneously produced in …

Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most
prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share …

The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet
have nearly identical DNA binding specificities. To identify mechanisms that facilitate …

The senescent microenvironment and aged cells per se contribute to tissue remodeling,
chronic inflammation, and age-associated dysfunction. However, the metabolic and …

The G/T transversion rs35705950, located approximately 3 kb upstream of the MUC5B start
site, is the cardinal risk factor for idiopathic pulmonary fibrosis (IPF). Here, we investigate the …