Genetics of primary aldosteronism

UI Scholl - Hypertension, 2022 - Am Heart Assoc
Primary aldosteronism is considered the commonest cause of secondary hypertension. In
affected individuals, aldosterone is produced in an at least partially autonomous fashion in …

Primary aldosteronism: molecular medicine meets public health

EAB Azizan, WM Drake, MJ Brown - Nature Reviews Nephrology, 2023 - nature.com
Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

60 years of POMC: adrenal and extra-adrenal functions of ACTH

N Gallo-Payet - Journal of molecular endocrinology, 2016 - jme.bioscientifica.com
The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and
stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis …

Genetic causes of primary aldosteronism

E Seidel, J Schewe, UI Scholl - Experimental & Molecular Medicine, 2019 - nature.com
Primary aldosteronism is characterized by at least partially autonomous production of the
adrenal steroid hormone aldosterone and is the most common cause of secondary …

Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

UI Scholl, L Abriola, C Zhang… - The Journal of …, 2017 - Am Soc Clin Investig
Aldosterone-producing adenomas (APAs) are benign tumors of the adrenal gland that
constitutively produce the salt-retaining steroid hormone aldosterone and cause millions of …

Advances in the understanding of two-pore domain TASK potassium channels and their potential as therapeutic targets

X Fan, Y Lu, G Du, J Liu - Molecules, 2022 - mdpi.com
TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5,
are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is …

Genetic mechanisms of human hypertension and their implications for blood pressure physiology

E Seidel, UI Scholl - Physiological Genomics, 2017 - journals.physiology.org
Hypertension, or elevated blood pressure, constitutes a major public health burden that
affects more than 1 billion people worldwide and contributes to~ 9 million deaths annually …

Transcriptome pathway analysis of pathological and physiological aldosterone-producing human tissues

J Zhou, B Lam, SG Neogi, GSH Yeo, EAB Azizan… - …, 2016 - Am Heart Assoc
Primary aldosteronism is present in≈ 10% of hypertensives. We previously performed a
microarray assay on aldosterone-producing adenomas and their paired zona glomerulosa …

Elemental composition of game meat from Austria

K Ertl, R Kitzer, W Goessler - Food Additives & Contaminants: Part …, 2016 - Taylor & Francis
Concentrations of 26 elements (B, Na, Mg, P, S, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se,
Rb, Sr, Mo, Cd, Sb, Ba, Hg, Pb, U) in wild game meat from Austria were analysed using an …

Intrinsic adrenal TWIK-related acid-sensitive TASK channel dysfunction produces spontaneous calcium oscillations sufficient to drive AngII (Angiotensin II) …

CA Gancayco, MR Gerding, DT Breault… - …, 2022 - Am Heart Assoc
Background: Ion channel mutations in calcium regulating genes strongly associate with
AngII (angiotensin II)-independent aldosterone production. Here, we used an established …