Over 10,000 arthropod species are currently considered to be pest organisms. They are
estimated to contribute to the destruction of~ 14% of the world's annual crop production and …

Voltage-gated sodium (NaV) channels play a central role in the propagation of action
potentials in excitable cells in both humans and insects. Many venomous animals have …

Voltage-gated sodium channels initiate electrical signals and are frequently targeted by
deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor …

Voltage‐gated sodium channels (NaV channels) are essential for the initiation and
propagation of action potentials that critically influence our ability to respond to a diverse …

Covering: up to 2006Advances in NMR and mass spectrometry as well as in peptide
biochemistry coupled to modern methods in electrophysiology have permitted the isolation …

Chronic pain is a serious debilitating condition that affects; 20% of the world's population.
Currently available drugs fail to produce effective pain relief in many patients and have dose …

Numerous metazoans express venoms for the purpose of defense, competitor deterrence, or
prey capture. Peptide neurotoxins are particularly well represented in the venoms of …

The tarantula Haplopelma hainanum (Ornithoctonus hainana) is a very venomous spider
found widely in the hilly areas of Hainan province in southern China. Its venom contains a …

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that
exhibit unique pharmacological properties to modulate key membrane protein targets …

The spider venom peptide Huwentoxin-IV (HwTx-IV) 1 is a potent antagonist of hNav1. 7
(IC50 determined herein as 17±2nM). Nav1. 7 is a voltage-gated sodium channel involved …