In recent years, the move to study neurodegenerative disease using larger animal models
with brains that are more similar to humans has gained interest. While pigs have been used …

Objective. Given the rapid expansion of the field of neural stimulation and the rigorous
regulatory approval requirements required before these devices can be applied clinically, it …

Motor cortex stimulation via surgically implanted electrodes has been used as an off-label
treatment for chronic neuropathic pain, but its efficacy has not been fully established. We …

Neural interface devices interact with the central nervous system (CNS) to substitute for
some sort of functional deficit and improve quality of life for persons with disabilities. Design …

Decoding laminar information across deep brain structures and cortical regions is necessary
in order to understand the neuronal ensembles that represent cognition and memory. Large …

Recording and manipulating neuronal ensemble activity is a key requirement in advanced
neuromodulatory and behavior studies. Devices capable of both recording and manipulating …

Conspectus Implantable neurotechnology enables monitoring and stimulating of the brain
signals responsible for performing cognitive, motor, and sensory tasks. Electrode arrays …

Neurodegeneration in Parkinson's disease (PD) includes processes of chronic inflammation
and oxidative stress which are related to dysregulation in the homeostasis of iron …

Objective. During deep brain stimulation (DBS) the electrode–tissue interface (ETI) forms a
critical path between device and brain tissue. Although changes in the electrical double …

Background DBS is a well-established therapy for patients with PD and is an emerging
therapy for other neuropsychiatric disorders. Despite the rise in DBS usage, relatively little is …