Short retroposons (SINEs) are repetitive elements amplified in the genome via an RNA
intermediate, using the enzymatic machinery of autonomous retroposons (LINEs). SINEs are …

Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial
discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes …

The spinal muscular atrophy (SMA) region on chromosome 5q13 contains an inverted
duplication of about 500 kb, and deleterious mutations in the survival motor neuron 1 …

Hypermethylation of the BRCA1 promoter has previously been shown to cause reduced
mRNA expression in both breast and ovarian cancers. Nothing is yet known of the …

Clinical researchers, practicing physicians, patients, and the general public now live in a
world in which the 2.9 billion nucleotide codes of the human genome are available as a …

Sex hormone-binding globulin (SHBG) is the major sex steroid-binding protein in human
plasma and is produced by the liver. Plasma SHBG levels vary considerably between …

The expression of the breast cancer susceptibility protein BRCA2 is highly regulated in
human breast, ovary, and pancreatic cells. BRCA2 is not expressed in the non-dividing cells …

International Review of Cell and Molecular Biology presents current advances and
comprehensive reviews in cell biology--both plant and animal. Articles address structure and …

The expression of prostate-specific membrane antigen (PSMA) and prostate-specific antigen
(PSA), two well characterized marker proteins, remains highly active in the hormone …

BRCA1 and BRCA2 are major breast cancer susceptibility genes whose pathogenic variants
are associated with a significant increase in the risk of breast and ovarian cancers. Current …