Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

Glycolipids (such as glycoglycerolipids, glycosphingolipids, and
glycosylphosphatidylinositol) and lipoglycans (such as lipopolysaccharides (LPS) …

The membrane attack complex (MAC) is an important innate immune effector of the
complement terminal pathway that forms cytotoxic pores on the surface of microbes. Despite …

Proteins containing membrane attack complex/perforin (MACPF) domains play important
roles in vertebrate immunity, embryonic development, and neural-cell migration. In …

It is well established that the organ damage that complicates human diabetes is caused by
prolonged hyperglycemia, but the cellular and molecular mechanisms by which high levels …

Membrane attack is important for mammalian immune defense against invading
microorganisms and infected host cells. Proteins of the complement membrane attack …

The cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins that
are produced, secreted and contribute to the pathogenesis of many species of Gram-positive …

Snake venom neurotoxins and lymphocyte antigen 6 (Ly6) proteins, most of the latter being
membrane tethered by a glycosylphosphatidylinositol (GPI) anchor, have a variety of …

Dysregulated complement is thought to play a central role in age‐related macular
degeneration (AMD) pathogenesis, but the specific mechanisms have yet to be determined …