This review article focuses on pre-clinical and clinical studies with some selected Brazilian
medicinal plants in different areas of interest, conducted by research groups in Brazil and …

Inflammation is an adaptive response of the immune system to tissue malfunction or
homeostatic imbalance. Corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) …

The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over
the synthetic formulation of drugs. Senna is evolving as one of the important plants which …

The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …

Genus Senna belongs to the family of Fabaceae and comprises of about 250–300 accepted
species extensively dispersed in tropical and subtropical regions. The Senna species is …

Background Multiple dysregulated pathways are behind the pathogenesis of
neurodegenerative diseases (NDDs); however, the crucial targets are still unknown …

Ethnopharmacological relevance Pain is a multi-faceted and multi-factorial condition which
is challenging to manage and treat. Conventional therapies such as analgesics, Non …

Chronic pain conditions, such as neuropathic pain, are a common problem that poses a
major challenge to health‐care providers due to its complex natural history, unclear …

Neuropathic pain is a common symptom and is associated with an impaired quality of life. It
is caused by the lesion or disease of the somatosensory system. Neuropathic pain …

Background Behavioral assessment of mutant mouse models and novel candidate drugs is
a slow and labor intensive process. This limitation produces a significant impediment to CNS …