During the past twenty years, evidence has accumulated for the presence of phospholipids
within the nuclei of eukaryotic cells. These phospholipids are distinct from those that are …

The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively
investigated in diverse cell lines and pathological conditions. Among the PLC isozmes …

The NFE2 transcription factor was identified over 25 years ago. The NFE2 protein forms
heterodimers with small MAF proteins, and the resulting complex binds to regulatory …

Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways
which modulate many cellular functions including cell proliferation, cell differentiation …

Phospholipase C β1 (PLCβ1) signaling in both cell proliferation and differentiation has been
largely investigated, but its role in myoblast differentiation is still unclear. The C2C12 …

Phospholipid signaling has clear connections to a wide array of cellular processes,
particularly in gene expression and in controlling the chromatin biology of cells. However …

Dynamic regulation of chromatin structure is thought to be a prerequisite for nuclear
functions that require accessibility to DNA such as replication, transcription and DNA repair …

Strong evidence has been accumulating over the last 15 years suggesting that
phosphoinositides, which are involved in the regulation of a large variety of cellular …

Inositide signaling pathways can have a role in the Myelodysplastic Syndromes (MDS)
progression to acute myeloid leukemia. Erythropoietin (EPO) is currently used in low-risk …

Simple Summary This review highlights the role of phospholipase in lung cancer, a topic
which should be better elucidated considering that phospholipase signaling plays a crucial …