TA Quinn, P Kohl - Physiological reviews, 2021 - journals.physiology.org
The heart is vital for biological function in almost all chordates, including humans. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing …
Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …
N Schmitt, M Grunnet, SP Olesen - Physiological reviews, 2014 - journals.physiology.org
About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K+ channels are primarily responsible for early repolarization …
A Djillani, J Mazella, C Heurteaux… - Frontiers in …, 2019 - frontiersin.org
TREK-1 is the most studied background K2P channel. Its main role is to control cell excitability and maintain the membrane potential below the threshold of depolarization …
S Hughes, S McBain, J Dobson… - Journal of the Royal …, 2008 - royalsocietypublishing.org
This study reports the preliminary development of a novel magnetic particle-based technique that permits the application of highly localized mechanical forces directly to …
DP Lotshaw - Cell biochemistry and biophysics, 2007 - Springer
The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15 KCNK genes and subdivided into six subfamilies on the basis of sequence similarities …
Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the resting membrane potential and modulate action potential repolarization. Members of the …
E Peprah, H Xu, F Tekola-Ayele, CD Royal - Public Health Genomics, 2015 - karger.com
Genomic research is one of the tools for elucidating the pathogenesis of diseases of global health relevance and paving the research dimension to clinical and public health translation …
SCM Choisy, LA Arberry, JC Hancox, AF James - Hypertension, 2007 - Am Heart Assoc
Although hypertension is the most prevalent risk factor for atrial fibrillation, there is currently no information available from animal models of hypertension regarding the development of …