Molecular background of leak K+ currents: two-pore domain potassium channels
P Enyedi, G Czirják - Physiological reviews, 2010 - journals.physiology.org
Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …
The well-known role of background K+ currents is to stabilize the negative resting …
Cardiac mechano-electric coupling: acute effects of mechanical stimulation on heart rate and rhythm
The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …
continually throughout our life, supplying the body with oxygen and nutrients while removing …
Cardiac mechano-gated ion channels and arrhythmias
Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …
Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …
potential. Some of the K+ channels are primarily responsible for early repolarization …
Role of TREK-1 in health and disease, focus on the central nervous system
A Djillani, J Mazella, C Heurteaux… - Frontiers in …, 2019 - frontiersin.org
TREK-1 is the most studied background K2P channel. Its main role is to control cell
excitability and maintain the membrane potential below the threshold of depolarization …
excitability and maintain the membrane potential below the threshold of depolarization …
Selective activation of mechanosensitive ion channels using magnetic particles
This study reports the preliminary development of a novel magnetic particle-based
technique that permits the application of highly localized mechanical forces directly to …
technique that permits the application of highly localized mechanical forces directly to …
Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels
DP Lotshaw - Cell biochemistry and biophysics, 2007 - Springer
The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15
KCNK genes and subdivided into six subfamilies on the basis of sequence similarities …
KCNK genes and subdivided into six subfamilies on the basis of sequence similarities …
Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
F Wiedmann, N Frey, C Schmidt - Cells, 2021 - mdpi.com
Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …
resting membrane potential and modulate action potential repolarization. Members of the …
Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease
E Peprah, H Xu, F Tekola-Ayele, CD Royal - Public Health Genomics, 2015 - karger.com
Genomic research is one of the tools for elucidating the pathogenesis of diseases of global
health relevance and paving the research dimension to clinical and public health translation …
health relevance and paving the research dimension to clinical and public health translation …
Increased susceptibility to atrial tachyarrhythmia in spontaneously hypertensive rat hearts
Although hypertension is the most prevalent risk factor for atrial fibrillation, there is currently
no information available from animal models of hypertension regarding the development of …
no information available from animal models of hypertension regarding the development of …