Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …

Many vaccines induce protective immunity via antibodies. Systems biology approaches
have been used to determine signatures that can be used to predict vaccine-induced …

Despite widespread use of the bacille Calmette–Guérin (BCG) vaccine, tuberculosis (TB)
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …

Our understanding of the origin and functions of human blood CXCR5+ CD4+ T cells found
in human blood has changed dramatically in the past years. These cells are currently …

A major goal of systems biology is the development of models that accurately predict
responses to perturbation. Constructing such models requires the collection of dense …

Objective The role of interferon‐α (IFNα) in the pathogenesis of systemic lupus
erythematosus (SLE) is strongly supported by gene expression studies. The aim of this study …

Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis
infection to pulmonary tuberculosis disease in humans remains limited. To define such …

Abstract Systems-biology approaches in immunology take various forms, but here we review
strategies for measuring a broad swath of immunological functions as a means of …