Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Programmed cell death is a genetically regulated process of cell suicide that is central to the
development, homeostasis and integrity of multicellular organisms. Conversely, the …

Pro-and anti-apoptotic members of the Bcl-2 family control the permeability of the outer
mitochondrial membrane. They could do this either by forming autonomous pores in the …

Mitochondria are well known as sites of electron transport and generators of cellular ATP.
Mitochondria also appear to be sites of cell survival regulation. In the process of …

The mitochondrial outer membrane is not just a barrier but a site of regulation of
mitochondrial function. The VDAC family of proteins are the major pathways for metabolite …

Apoptosis is associated in many cases with the generation of reactive oxygen species (ROS)
in cells across a wide range of organisms including lower eukaryotes such as the yeast …

The high turnover of endothelial cells (EC) in atherosclerosis suggests that an increase in
the frequency of both cell proliferation and cell death is important in the pathogenesis of this …

In this review I summarize interrelations between bioenergetic processes and such
programmed death phenomena as cell suicide (apoptosis and necrosis) and mitochondrial …

Two major intracellular apoptosis signaling cascades have been characterized, the
mitochondrial pathway and the death receptor pathway. The mitochondrial pathway is …

Evidence is presented that mitochondria are implicated in the previously described
programmed cell death (PCD) process induced by acetic acid in Saccharomyces cerevisiae …