Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …

Initially, the E2F transcription factor was discovered as a factor able to bind the adenovirus
E2 promoter and activate viral genes. Afterwards it was shown that E2F also binds to …

Background: Circular RNAs (circRNAs), as covalently closed single-stranded noncoding
RNA molecules, have been recently identified to involve in several biological processes …

Background Breast cancer brain metastases (BCBM) develop in about 20–30% of breast
cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to lack of …

Abstract About 50–70% of breast cancers are estrogen receptor α (ERα) positive and most of
them are sensitive to endocrine therapy including tamoxifen. However, one third of these …

Abstract Karyopherin alpha 2 (KPNA2) is a nuclear import factor that is elevated in multiple
cancers. However, its molecular regulation at the transcriptional levels is poorly understood …

The mammalian cell cycle is controlled by the E2F family of transcription factors. Typical
E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins …

The endoplasmic reticulum (ER) has recently emerged as an alternative target to induce cell
death in tumours, because prolonged ER stress results in the induction of apoptosis even in …

Although derivation of naïve bovine embryonic stem cells is unachieved, the possibility for
generation of bovine induced pluripotent stem cells (biPSCs) has been generally reported …

We here tested expression and potential functions of circular RNA PRKCI (circPRKCI) in
human glioma. Our results show that circPRKCI is upregulated in human glioma tissues and …