A fundamental challenge in biology is understanding the molecular details of protein
function. How mutations alter protein activity, regulation, and response to drugs is of critical …

Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …

CRISPR base editing screens enable analysis of disease-associated variants at scale;
however, variable efficiency and precision confounds the assessment of variant-induced …

CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell
function and has nominated candidate targets for immunotherapies,,,,–. However, new …

Natural killer (NK) cells are a critical first line of defense against viral infection. Rare
mutations in a small subset of transcription factors can result in decreased NK cell numbers …

CRISPR screens with single-cell transcriptomic readouts are a valuable tool to understand
the effect of genetic perturbations including single nucleotide variants (SNVs) associated …

Genome-wide association studies (GWAS) have underrepresented individuals from non-
European populations, impeding progress in characterizing the genetic architecture and …

Single-nucleotide variants (SNVs) in key T cell genes can drive clinical pathologies and
could be repurposed to improve cellular cancer immunotherapies. Here, we perform …

Population-scale single-cell genomics is a transformative approach for unraveling the
intricate links between genetic and cellular variation. This approach is facilitated by cutting …

Despite ground-breaking genetic studies that have identified thousands of risk variants for
developmental diseases, how these variants lead to molecular and cellular phenotypes …