Objective Insertion of tympanostomy tubes is the most common ambulatory surgery
performed on children in the United States. Tympanostomy tubes are most often inserted …

Inflammation of the middle ear, known clinically as chronic otitis media, presents in different
forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative …

Objective Insertion of tympanostomy tubes is the most common ambulatory surgery
performed on children in the United States. Tympanostomy tubes are most often inserted …

Objective This update of a 2004 guideline codeveloped by the American Academy of
Otolaryngology—Head and Neck Surgery Foundation, the American Academy of Pediatrics …

Background All mucosal epithelia, including those of the tubotympanium, are secreting a
variety of antimicrobial innate immune molecules (AIIMs). In our previous study, we showed …

Craniofacial defects that occur through gene mutation during development increase
vulnerability to eustachian tube dysfunction. These defects can lead to an increased …

This study was designed to understand the contribution of the inflammasome and IL-1β
activation in otitis media (OM). We examined the middle ear (ME) response to non-typeable …

OBJECTIVE: A novel mouse model with a specific genetic mutation in a G protein coupled
receptor (GPCR) encoded by the Oxgr1 gene results in a predisposition to spontaneous …

Streptococcus pneumoniae is the most common pathogen associated with otitis media. To
examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus …

Abstract Mucin gene 19 (MUC19) has been identified as a major gel-forming mucin in the
human middle ear (ME). The objectives of this investigation were to characterize the …