Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Long viewed as an intermediary in protein translation, there is a growing awareness that
transfer RNAs (tRNAs) are capable of myriad other biological functions linked to human …

Although deregulation of transfer RNA (tRNA) biogenesis promotes the translation of pro-
tumorigenic mRNAs in cancers,, the mechanisms and consequences of tRNA deregulation …

Transfer RNAs (tRNAs) are small adaptor RNAs essential for mRNA translation. Alterations
in the cellular tRNA population can directly affect mRNA decoding rates and translational …

Cultivated meat is emerging to replace traditional livestock industries, which have ecological
costs, including land and water overuse and considerable carbon emissions. During …

Transcription of tRNA genes by RNA polymerase III (RNAPIII) is tuned by signaling
cascades. The emerging notion of differential tRNA gene regulation implies the existence of …

A key characteristic of cancer cells is their increased proliferative capacity, which requires
elevated levels of protein synthesis. The process of protein synthesis involves the translation …

Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

Oligodendrocytes are specialized cells that confer neuronal myelination in the central
nervous system. Leukodystrophies associated with oligodendrocyte deficits and …

Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing
endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur …