ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

ADP-ribosylation is a chemical modification of macromolecules found across all domains of
life and known to regulate a variety of cellular processes. Notably, it has a well-established …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated
by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself …

PARP1 mediates poly-ADP-ribosylation of proteins on chromatin in response to different
types of DNA lesions. PARP inhibitors are used for the treatment of BRCA1/2-deficient …

In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …

Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …

Abstract Although Poly (ADP-ribose)-polymerases (PARPs) are key regulators of genome
stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we …

We report here chemoenzymatic and fully synthetic methodologies to modify aspartate and
glutamate side chains with ADP-ribose at specific sites on peptides. Structural analysis of …

The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much
remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the …