The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size
affect cell physiology. To address this, we measured how the cell's proteome changes with …

Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …

The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

Despite decades of research, how mammalian cell size is controlled remains unclear
because of the difficulty of directly measuring growth at the single-cell level. Here we report …

A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

Cell density shows very little variation within a given cell type. For example, in humans
variability in cell density among cells of a given cell type is 100 times smaller than variation …

The size of a cell is determined by a combination of synthesis, self-assembly, incoming
matter and the balance of mechanical forces. Such processes operate at the single-cell …

Ploidy and size phenomena are observed to be correlated across several biological scales,
from subcellular to organismal. Two kinds of ploidy change can affect plants. Whole-genome …