Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone
core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA …

Epigenetic marks are reprogrammed in the gametes to reset genomic potential in the next
generation. In mammals, paternal chromatin is extensively reprogrammed through the …

Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

As the building blocks of chromatin, histones are central to establish and maintain particular
chromatin states associated with given cell fates. Importantly, histones exist as distinct …

Cellular differentiation is associated with dynamic chromatin remodeling in establishing a
cell-type-specific epigenomic landscape. Here, we find that mouse testis-specific and …

Di‐or tri‐methylated H3K9 (H3K9me2/3) is an epigenetic mark of heterochromatin.
Heterochromatin protein 1 (HP1) specifically recognizes H3K9me2/3, contributing to …

Histone post-translational modifications (PTMs) are one of the main mechanisms of
epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such …