For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

DNA is commonly known as the “molecule of life” because it holds the genetic instructions
for all living organisms on Earth. The utilization of modified nucleosides holds the potential …

A range of lipophilic prodrugs of α-carboxy nucleoside phosphonates, potent inhibitors of
HIV-1 reverse transcriptase without requiring prior phosphorylation, were synthesized to …

New acyclic pyrimidine nucleoside phosphonate prodrugs with a 4-(2, 4-diaminopyrimidin-6-
yl) oxy-but-2-enyl] phosphonic acid skeleton (O-DAPy nucleobase) were prepared through a …

A series of seventeen hitherto unknown ANP analogs bearing the (E)-but-2-enyl aliphatic
side chain and modified heterocyclic base such as cytosine and 5-fluorocytosine, 2 …

Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs)
were prepared directed with nitrogen reagents by cross-metathesis in water-under …

The synthesis of new class of potential TPase inhibitors containing a
difluoromethylphosphonate function as phosphate mimic is reported. This new series was …

Emerging and reemerging viruses pose significant public health threats, underscoring the
urgent need for new antiviral drugs. Recently, a novel family of antiviral acyclic nucleoside …

Seventeen hitherto unknown bis (POM) prodrugs of novel (E)-[4′-phosphono-but-2′-en-
1′-yl] purine nucleosides were prepared in a straight approach and at good yields. Those …

A series of hitherto unknown (1, 4-disubstituted-1, 2, 3-triazol)-(E)-2-methyl-but-2-enyl
nucleosides phosphonate prodrugs bearing 4-substituted-1, 2, 3-triazoles were prepared in …