Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …

Purpose To provide an overview of current clinical results of irreversible electroporation
(IRE), a novel, nonthermal tumor ablation technique that uses electric pulses to induce cell …

Background The role of chemoradiation with systemic chemotherapy compared with
chemotherapy alone in locally advanced pancreatic cancer (LAPC) is uncertain. Patients …

Pancreatic ductal adenocarcinoma is one of the most difficult malignancies to diagnose and
treat. The aim of this article is to review how tumor markers can aid the diagnosis and …

Background Single-agent gemcitabine (GEM) is a standard treatment for advanced and
metastatic pancreatic cancer. This study examines the question whether GEM-based …

Background Pancreatic cancer (PC) is a highly lethal disease with few effective treatment
options. Over the past few decades, many anti‐cancer therapies have been tested in the …

PURPOSE: Fractionated radiotherapy and chemotherapy for locally advanced pancreatic
cancer achieves only modest local control. This prospective trial evaluated the efficacy of a …

Purpose: To carry out an integrative profile of human pancreatic ductal adenocarcinoma
(PDAC) to identify prognosis-significant genes and their related pathways. Experimental …

Purpose Pancreatic carcinoma is one of the leading causes of cancer-related mortality. At
time of diagnosis, 30% of patients present with a locally advanced unresectable but …

There is no consensus on the management of locally advanced pancreatic cancer, with
either chemotherapy or combined modality approaches being employed (Maheshwari and …