Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Severe congenital neutropenias
Severe congenital neutropenias are a heterogeneous group of rare haematological
diseases characterized by impaired maturation of neutrophil granulocytes. Patients with …
diseases characterized by impaired maturation of neutrophil granulocytes. Patients with …
Complex tissue and disease modeling using hiPSCs
Defined genetic models based on human pluripotent stem cells have opened new avenues
for understanding disease mechanisms and drug screening. Many of these models assume …
for understanding disease mechanisms and drug screening. Many of these models assume …
Mouse models of neutropenia reveal progenitor-stage-specific defects
DE Muench, A Olsson, K Ferchen, G Pham, RA Serafin… - Nature, 2020 - nature.com
Advances in genetics and sequencing have identified a plethora of disease-associated and
disease-causing genetic alterations. To determine causality between genetics and disease …
disease-causing genetic alterations. To determine causality between genetics and disease …
Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors
Diamond-Blackfan anemia (DBA) is a congenital disorder characterized by the failure of
erythroid progenitor differentiation, severely curtailing red blood cell production. Because …
erythroid progenitor differentiation, severely curtailing red blood cell production. Because …
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice
R Mou, J Ma, X Ju, Y Wu, Q Chen, J Li, T Shang… - Cell Stem Cell, 2024 - cell.com
Psychological stress is often linked to depression and can also impact the immune system,
illustrating the interconnectedness of mental health and immune function. Hematopoietic …
illustrating the interconnectedness of mental health and immune function. Hematopoietic …
How I manage children with neutropenia
DC Dale - British journal of haematology, 2017 - Wiley Online Library
Neutropenia, usually defined as a blood neutrophil count< 1· 5× 109/l, is a common medical
problem for children and adults. There are many causes for neutropenia, and at each stage …
problem for children and adults. There are many causes for neutropenia, and at each stage …
Classical inherited bone marrow failure syndromes with high risk for myelodysplastic syndrome and acute myelogenous leukemia
The inherited marrow failure syndromes (IBMFS) are a heterogeneous group of diseases
characterized by failure in the production of one or more blood lineage. The clinical …
characterized by failure in the production of one or more blood lineage. The clinical …
Proteome analysis of human neutrophil granulocytes from patients with monogenic disease using data-independent acquisition*[S]
Neutrophil granulocytes are critical mediators of innate immunity and tissue regeneration.
Rare diseases of neutrophil granulocytes may affect their differentiation and/or functions …
Rare diseases of neutrophil granulocytes may affect their differentiation and/or functions …
[HTML][HTML] Dissecting ELANE neutropenia pathogenicity by human HSC gene editing
Severe congenital neutropenia (SCN) is a life-threatening disorder most often caused by
dominant mutations of ELANE that interfere with neutrophil maturation. We conducted a …
dominant mutations of ELANE that interfere with neutrophil maturation. We conducted a …