Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play
important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In …

Drugs are typically small molecules that are generally classified as xenobiotics, which are
foreign to the human body. Several endogenous molecules, however, such as steroids and …

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective
effects. Interest in this compound has been renewed in recent years, first from its …

Organ interactions resulting from drug, metabolite or xenobiotic transport between organs
are key components of human metabolism that impact therapeutic action and toxic side …

Human cytochrome P450 (CYP) 3A4 is the most abundant hepatic and intestinal phase I
enzyme that metabolizes approximately 50% marketed drugs. The crystal structure of bound …

The discovery and development of a novel irreversible EGFR/HER2 dual tyrosine kinase
inhibitor SHR1258 (pyrotinib) for the treatment of HER2-postive breast cancer is presented …

A systematic review of cohort studies, randomized trials, voluntary notifications to national
regulatory authorities, and published case reports was undertaken to assess the incidence …

Physiological, hormonal, and genetic differences between males and females affect the
prevalence, incidence, and severity of diseases and responses to therapy. Understanding …

This review summarizes important studies regarding Helicobacter pylori therapy published
from April 2019 to April 2020. The main themes that emerge involve studies assessing …