ABSTRACT p63 (also known as TP63) is a transcription factor of the p53 family, along with
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …

Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell
compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and …

The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

The p53 transcription factor confers its potent tumor suppressor functions primarily through
the regulation of a large network of target genes. The recent explosion of next generation …

Tissue development results from lineage-specific transcription factors (TFs) programming a
dynamic chromatin landscape through progressive cell fate transitions. Here, we define …

Skin stem cells distributed in the basal layer of the epidermis and hair follicles are important
cell sources for skin development, metabolism, and injury repair. At present, great progress …

Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable
platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) …

Proper ectodermal patterning during human development requires previously identified
transcription factors such as GATA3 and p63, as well as positional signalling from regional …