Abstract G-quadruplexes (G4) are secondary four-stranded DNA helical structures
consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

Noncanonical nucleic acid structures, such as G-quadruplex (G4) and i-Motif (iM), have
attracted increasing research interests because of their unique structural and binding …

In many organisms, antimicrobial peptides (AMPs) display wide activities in innate host
defense against microbial pathogens. Mammalian AMPs include the cathelicidin and …

ε-poly-l-Lysine (ε-PLL) peptide is a product of the marine bacterium Bacillus subtilis with
antibacterial and anticancer activity largely used worldwide as a food preservative. ε-PLL …

G-Quadruplex (GQ) nucleic acids are promising therapeutic targets in anticancer research
due to their structural robustness, polymorphism, and gene-regulatory functions. Here, we …

Aims In this study, a series of novel naphthalimide-benzotriazole conjugates (1a–3c) based
on 1, 8-naphthalimide as a core skeleton, aiming at G-quadruplexes, were designed and …

c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its
deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After …

G‐Quadruplex (GQ) and i‐motif structures are the paradigmatic examples of nonclassical
tetrastranded nucleic acids having multifarious biological functions and widespread …

Abstract c-MYC proto-oncogene harbors a putative G-quadruplex structure (Pu27) at the
NHEIII 1 domain, which can shuffle between transcriptional inhibitor quadruplex and …