Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular
communication by delivering bioactive cargo over short and long distances. Short-distance …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Actin is the most abundant protein in most eukaryotic cells. It is highly conserved and
participates in more protein-protein interactions than any known protein. These properties …

Summary Actin-depolymerizing factor (ADF)/cofilins contribute to cytoskeletal dynamics by
promoting rapid actin filament disassembly. In the classical view, ADF/cofilin sever filaments …

Cofilin is best known for its ability to sever actin filaments and facilitate cytoskeletal recycling
inside of cells, but at higher concentrations in vitro, cofilin stabilizes a more flexible, hyper …

Actin-based motility demands the spatial and temporal coordination of numerous regulatory
actin-binding proteins (ABPs)[1], many of which bind with affinities that depend on the …

High-speed atomic force microscopy was employed to observe structural changes in actin
filaments induced by cofilin binding. Consistent with previous electron and fluorescence …

Eukaryotic cells generate a diversity of actin filament networks in a common cytoplasm to
optimally perform functions such as cell motility, cell adhesion, endocytosis and cytokinesis …

Actin filaments and myosin II are evolutionarily conserved force-generating components of
the contractile ring during cytokinesis. Here we show that in budding yeast, actin filament …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are the central regulators of
actin filament disassembly. A key function of ADF/cofilin is to sever actin filaments. However …