Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …

Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is
thought to result from the effect of environmental factors in a genetically predisposed host. A …

Epistasis, the interaction between genes, is a topic of current interest in molecular and
quantitative genetics. A large amount of research has been devoted to the detection and …

Initiation and perpetuation of the inflammatory intestinal responses in inflammatory bowel
disease (IBD) may result from an exaggerated host defense reaction of the intestinal …

The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are
recognized as important causes of gastrointestinal disease in children and adults. In this …

Interactions among loci or between genes and environmental factors make a substantial
contribution to variation in complex traits such as disease susceptibility. Nonetheless, many …

▪ Abstract Nods are cytosolic proteins that contain a nucleotide-binding oligomerization
domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance …

CARD15/NOD2 encodes a protein involved in bacterial recognition by monocytes. Mutations
in CARD15 have recently been found in patients with Crohn disease (CD), a chronic …

The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune …