The implication of 5-HT receptor family members in aggression, depression and suicide: similarity and difference
NK Popova, AS Tsybko, VS Naumenko - International journal of molecular …, 2022 - mdpi.com
Being different multifactorial forms of psychopathology, aggression, depression and suicidal
behavior, which is considered to be violent aggression directed against the self, have …
behavior, which is considered to be violent aggression directed against the self, have …
Genetics of aggressive behavior: an overview
K Veroude, Y Zhang‐James… - American Journal of …, 2016 - Wiley Online Library
The Research Domain Criteria (RDoC) address three types of aggression: frustrative non‐
reward, defensive aggression and offensive/proactive aggression. This review sought to …
reward, defensive aggression and offensive/proactive aggression. This review sought to …
Targeting nuclear receptors in neurodegeneration and neuroinflammation
S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …
expression upon ligand signals and present as attractive therapeutic targets especially in …
TLX: A master regulator for neural stem cell maintenance and neurogenesis
The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural
stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is …
stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is …
The stalk-eyed fly as a model for aggression–is there a conserved role for 5-HT between vertebrates and invertebrates?
ABSTRACT Serotonin (5-HT) has largely been accepted to be inhibitory to vertebrate
aggression, whereas an opposing stimulatory role has been proposed for invertebrates …
aggression, whereas an opposing stimulatory role has been proposed for invertebrates …
Aggression in non‐human vertebrates: Genetic mechanisms and molecular pathways
F Freudenberg, H Carreño Gutierrez… - American Journal of …, 2016 - Wiley Online Library
Aggression is an adaptive behavioral trait that is important for the establishment of social
hierarchies and competition for mating partners, food, and territories. While a certain level of …
hierarchies and competition for mating partners, food, and territories. While a certain level of …
Nuclear receptors in neural stem/progenitor cell homeostasis
D Gkikas, M Tsampoula, PK Politis - Cellular and Molecular Life Sciences, 2017 - Springer
In the central nervous system, embryonic and adult neural stem/progenitor cells (NSCs)
generate the enormous variety and huge numbers of neuronal and glial cells that provide …
generate the enormous variety and huge numbers of neuronal and glial cells that provide …
Predation stress causes excessive aggression in female mice with partial genetic inactivation of tryptophan hydroxylase-2: evidence for altered myelination-related …
The interaction between brain serotonin (5-HT) deficiency and environmental adversity may
predispose females to excessive aggression. Specifically, complete inactivation of the gene …
predispose females to excessive aggression. Specifically, complete inactivation of the gene …
Regulation of behaviour by the nuclear receptor TLX
The orphan nuclear receptor Tlx (Nr2e1) is a key regulator of both embryonic and adult
hippocampal neurogenesis. Several different mouse models have been developed which …
hippocampal neurogenesis. Several different mouse models have been developed which …
TLX—its emerging role for neurogenesis in health and disease
PK Sobhan, K Funa - Molecular Neurobiology, 2017 - Springer
The orphan nuclear receptor TLX, also called NR2E1, is a factor important in the regulation
of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription …
of neural stem cell (NSC) self-renewal, neurogenesis, and maintenance. As a transcription …