[HTML][HTML] Appropriate therapeutic drug monitoring of biologic agents for patients with inflammatory bowel diseases

K Papamichael, AS Cheifetz, GY Melmed… - Clinical …, 2019 - Elsevier
Background & Aims Therapeutic drug monitoring (TDM) is widely available for biologic
therapies in patients with inflammatory bowel disease (IBD). We reviewed current data and …

Immunogenicity of biologics in chronic inflammatory diseases: a systematic review

V Strand, A Balsa, J Al-Saleh, L Barile-Fabris… - BioDrugs, 2017 - Springer
Objectives A systematic review was conducted to explore the immunogenicity of biologic
agents across inflammatory diseases and its potential impact on efficacy/safety. Methods …

American Gastroenterological Association Institute technical review on the role of therapeutic drug monitoring in the management of inflammatory bowel diseases

NV Casteele, H Herfarth, J Katz, Y Falck-Ytter, S Singh - Gastroenterology, 2017 - Elsevier
Therapeutic drug monitoring (TDM), which involves measurement of drug or active
metabolite levels and anti-drug antibodies, is a promising strategy that can be used to …

consensus statements on therapeutic drug monitoring of anti‐tumour necrosis factor therapy in inflammatory bowel diseases

N Mitrev, N Vande Casteele, CH Seow… - Alimentary …, 2017 - Wiley Online Library
Background Therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD)
patients receiving anti‐tumour necrosis factor (TNF) agents can help optimise outcomes …

Immunogenicity of TNF-inhibitors

S Atiqi, F Hooijberg, FC Loeff, T Rispens… - Frontiers in …, 2020 - frontiersin.org
Tumor necrosis factor inhibitors (TNFi) have significantly improved treatment outcome of
rheumatic diseases since their incorporation into treatment protocols two decades ago …

Proactive therapeutic drug monitoring of adalimumab is associated with better long-term outcomes compared with standard of care in patients with inflammatory bowel …

K Papamichael, A Juncadella, D Wong… - Journal of Crohn's …, 2019 - academic.oup.com
Abstract Background and Aims Therapeutic drug monitoring [TDM] has proven to be
effective for optimising anti-tumour necrosis factor [TNF] therapy in inflammatory bowel …

Optimizing biologic therapy in IBD: how essential is therapeutic drug monitoring?

M Argollo, PG Kotze, P Kakkadasam… - Nature Reviews …, 2020 - nature.com
Proposed treatment targets for the management of inflammatory bowel disease (IBD) have
moved beyond symptomatic improvement towards more objective end points, such as …

Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease

BL Cohen, DB Sachar - Bmj, 2017 - bmj.com
The treatment of inflammatory bowel disease (IBD)—ulcerative colitis (UC) and Crohn's
disease (CD)—has evolved beyond surgery with the introduction of biologic agents …

Influence of early adalimumab serum levels on immunogenicity and long‐term outcome of anti‐TNF naive Crohn's disease patients: the usefulness of rapid testing

B Verstockt, G Moors, S Bian… - Alimentary …, 2018 - Wiley Online Library
Background Proactive testing of adalimumab serum levels is debated. Aim To study the
association between adalimumab serum levels at week 4 and the development of anti …

Prospective observational evaluation of time-dependency of adalimumab immunogenicity and drug concentrations: the POETIC study

B Ungar, T Engel, D Yablecovitch, A Lahat… - Official journal of the …, 2018 - journals.lww.com
OBJECTIVES: Adalimumab is usually self-injected at home, making prospective serial-
sampling studies challenging and scarce. This has led to a gap in knowledge about …