[HTML][HTML] Immune mechanisms of toxicity from checkpoint inhibitors

SJ Wang, SK Dougan, M Dougan - Trends in cancer, 2023 - cell.com
Immunotherapy has changed the treatment landscape for cancer over the past decade.
Inhibitors of the immune checkpoint proteins cytotoxic T lymphocyte antigen (CTLA)-4 …

Gastrointestinal mucosal toxicities from immune checkpoint inhibitors: current understanding and future directions

M Dougan - Immunological Reviews, 2023 - Wiley Online Library
Immune checkpoint inhibitor (ICI) therapy has revolutionized the field of oncology over the
past decade, leading to durable remissions in some patients but also producing a wide …

Checkpoint inhibitor-induced colitis: an update

G Losurdo, D Angelillo, N Favia, MC Sergi, A Di Leo… - Biomedicines, 2023 - mdpi.com
Immunotherapy with immune checkpoint inhibitors (ICIs) nowadays has indications for
several solid tumors. The current targets for ICIs are CTLA-4, PD-1, and PD-L1 receptors …

Update on immune checkpoint inhibitor enterocolitis

MR Kelly-Goss, YR Badran, M Dougan - Current Gastroenterology Reports, 2022 - Springer
Abstract Purpose of Review Immune checkpoint inhibitor (ICI) therapy revolutionized the
treatment of multiple solid and hematologic malignancies. Yet, with it came profound …

An updated review of gastrointestinal toxicity induced by PD-1 inhibitors: from mechanisms to management

Y Cheng, F Ling, J Li, Y Chen, M Xu, S Li… - Frontiers in …, 2023 - frontiersin.org
PD-1 inhibitors, as one of commonly used immune checkpoint inhibitors, enable T-cell
activation and prevent immune escape by blocking the PD-1/PD-L1 signaling pathway. They …

[HTML][HTML] Immune Checkpoint Inhibitor-Associated Celiac Disease: A Retrospective Analysis and Literature Review

M Gupta, C Graham, S Gupta - Diseases, 2024 - mdpi.com
Introduction: Immune checkpoint inhibitors (ICI) are used to treat various malignancies. They
block the inhibitory signals of tumor cells and enhance the inflammatory cascade, which …

[PDF][PDF] When genetic polymorphism meets an immune checkpoint inhibitor in celiac disease

A Lerner, C Benzvi - Int. J. Celiac Dis, 2022 - researchgate.net
Immune checkpoint inhibitors are increasingly used as adjuvant therapy in oncology;
however, they have short and long-term side effects. A major one is the surge in …

Primate liver tissue substrate in indirect immunofluorescence diagnostics for patients with dermatitis herpetiformis and celiac disease

F Schauer, G Tasiopoulou, D Schuster… - Frontiers in …, 2023 - frontiersin.org
Introduction Dermatitis herpetiformis (DH) is a rare autoimmune, polymorphous blistering
disorder, characterized by severe itch or burning sensation, which represents the cutaneous …

Managing adverse effects of novel immunotherapies in pancreatic and colon cancers

Z Ahmed, SO Ahmad, S Ahmad - Immune Therapy for Pancreatic and Colon …, 2025 - Elsevier
Immune checkpoint inhibitors (ICIs) have become the most frequently utilized
immunotherapy in solid tumors. Following their success in treating melanoma and lung …

Side effects, toxicity and ADRs of monoclonal antibodies in multiple organ systems

B Zhang, R Kumar, SD Ray - Side Effects of Drugs Annual, 2022 - Elsevier
The review of publications on the safety profiles of three different immunosuppressants and
immunomodulators (Alemtuzumab (ALZ), ipilimumab and nivolumab) published between …